TY  - JOUR
A1  - Rezende Felipe, Flávia Figueiredo de
A1  - Malacarne, Pedro Felipe
A1  - Müller, Niklas
A1  - Rathkolb, Birgit
A1  - Hrabě de Angelis, Martin
A1  - Schröder, Katrin
A1  - Brandes, Ralf
T1  - Nox4 maintains blood pressure during low sodium diet
T2  - Antioxidants
N2  - The NADPH oxidase Nox4 is a hydrogen peroxide (H2O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/- mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/- mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/- as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/- mice, resulting in lower blood pressure in response to low sodium.
KW  - NADPH oxidase 4
KW  - proximal tubule cells
KW  - reactive oxygen species
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61815
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-618155
SN  - 2076-3921
VL  - 10
IS  - 7, art. 1103
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -