TY  - JOUR
A1  - Grützner, Christine
A1  - Wibral, Michael
A1  - Sun, Limin
A1  - Rivolta, Davide
A1  - Singer, Wolf
A1  - Maurer, Konrad
A1  - Uhlhaas, Peter J.
T1  - Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
T2  - Frontiers in human neuroscience
N2  - Current theories of the pathophysiology of schizophrenia have focused on abnormal temporal coordination of neural activity. Oscillations in the gamma-band range (>25 Hz) are of particular interest as they establish synchronization with great precision in local cortical networks. However, the contribution of high gamma (>60 Hz) oscillations toward the pathophysiology is less established. To address this issue, we recorded magnetoencephalographic (MEG) data from 16 medicated patients with chronic schizophrenia and 16 controls during the perception of Mooney faces. MEG data were analysed in the 25–150 Hz frequency range. Patients showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces while responses to inverted stimuli were intact. Impaired processing of Mooney faces in schizophrenia patients was accompanied by a pronounced reduction in spectral power between 60–120 Hz (effect size: d = 1.26) which was correlated with disorganized symptoms (r = −0.72). Our findings demonstrate that deficits in high gamma-band oscillations as measured by MEG are a sensitive marker for aberrant cortical functioning in schizophrenia, suggesting an important aspect of the pathophysiology of the disorder.
KW  - MEG
KW  - gamma
KW  - schizophrenia
KW  - perceptual organization
KW  - synchrony
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/29809
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-298098
SN  - 1662-5161
N1  - Copyright © 2013 Grützner, Wibral, Sun, Rivolta, Singer, Maurer and Uhlhaas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
VL  - 7
IS  - Article 88
SP  - 1
EP  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -