TY  - JOUR
A1  - Schmidt, Stanislaw
A1  - Tramsen, Lars
A1  - Rais, Bushra
A1  - Ullrich, Evelyn
A1  - Lehrnbecher, Thomas
T1  - Natural killer cells as a therapeutic tool for infectious diseases - current status and future perspectives
T2  - OncoTarget
N2  - Natural Killer (NK) cells are involved in the host immune response against infections due to viral, bacterial and fungal pathogens, all of which are a significant cause of morbidity and mortality in immunocompromised patients. Since the recovery of the immune system has a major impact on the outcome of an infectious complication, there is major interest in strengthening the host response in immunocompromised patients, either by using cytokines or growth factors or by adoptive cellular therapies transfusing immune cells such as granulocytes or pathogen-specific T-cells. To date, relatively little is known about the potential of adoptively transferring NK cells in immunocompromised patients with infectious complications, although the anti-cancer property of NK cells is already being investigated in the clinical setting. This review will focus on the antimicrobial properties of NK cells and the current standing and future perspectives of generating and using NK cells as immunotherapy in patients with infectious complications, an approach which is promising and might have an important clinical impact in the future.
KW  - natural killer cell
KW  - adoptive immunotherapy
KW  - virus
KW  - bacterium
KW  - fungus
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46747
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-467473
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 9
IS  - 29
SP  - 20891
EP  - 20907
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -