TY  - JOUR
A1  - Thomas, Christoph
A1  - Aller, Stephen G.
A1  - Beis, Konstantinos
A1  - Carpenter, Elisabeth P.
A1  - Chang, Geoffrey
A1  - Chen, Lei
A1  - Dassa, Elie
A1  - Dean, Michael
A1  - Duong Van Hoa, Franck
A1  - Ekiert, Damian
A1  - Ford, Robert
A1  - Gaudet, Rachelle
A1  - Gong, Xin
A1  - Holland, I. Barry
A1  - Huang, Yihua
A1  - Kahne, Daniel K.
A1  - Kato, Hiroaki
A1  - Koronakis, Vassilis
A1  - Koth, Christopher M.
A1  - Lee, Youngsook
A1  - Lewinson, Oded
A1  - Lill, Roland
A1  - Martinoia, Enrico
A1  - Murakami, Satoshi
A1  - Pinkett, Heather W.
A1  - Poolman, Bert
A1  - Rosenbaum, Daniel
A1  - Sarkadi, Balazs
A1  - Schmitt, Lutz
A1  - Schneider, Erwin
A1  - Shi, Yigong
A1  - Shyng, Show‐Ling
A1  - Slotboom, Dirk Jan
A1  - Tajkhorshid, Emad
A1  - Tieleman, Dirk Peter
A1  - Ueda, Kazumitsu
A1  - Váradi, András
A1  - Wen, Po‐Chao
A1  - Yan, Nieng
A1  - Zhang, Peng
A1  - Zheng, Hongjin
A1  - Zimmer, Jochen
A1  - Tampé, Robert
T1  - Structural and functional diversity calls for a new classification of ABC transporters
T2  - FEBS Letters
N2  - Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs:
KW  - ABC transporters
KW  - ATPases
KW  - cryo-EM
KW  - membrane proteins
KW  - molecular machines
KW  - phylogeny
KW  - primary active transporters
KW  - sequence alignment
KW  - structural biology
KW  - X-ray crystallography
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57017
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-570178
SN  - 1873-3468
SN  - 0014-5793
VL  - 2020
PB  - Wiley
CY  - Chichester
ER  -