TY  - JOUR
A1  - Ruzsics, Zsolt
A1  - Hoffmann, Katja
A1  - Riedl, André
A1  - Krawczyk, Adalbert
A1  - Widera, Marek
A1  - Sertznig, Helene
A1  - Schipper, Leonie
A1  - Kapper-Falcone, Valeria
A1  - Debreczeny, Monika
A1  - Ernst, Wolfgang
A1  - Grabherr, Reingard
A1  - Hengel, Hartmut
A1  - Harant, Hanna
T1  - A novel, broad-acting peptide inhibitor of double-stranded DNA virus gene expression and replication
T2  - Frontiers in microbiology
N2  - Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options, preferably with extended target range. In the present study, we describe a novel antiviral peptide with broad activity against several double-stranded DNA viruses. The 22-mer peptide TAT-I24 potently neutralized viruses such as herpes simplex viruses, adenovirus type 5, cytomegalovirus, vaccinia virus, and simian virus 40 in cell culture models, while being less active against RNA viruses. The peptide TAT-I24 therefore represents a novel and promising drug candidate for use against double-stranded DNA viruses.
KW  - antiviral peptide
KW  - herpes simplex virus
KW  - cytomegalovirus
KW  - adenovirus
KW  - polyomavirus
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57015
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-570152
SN  - 1664-302X
VL  - 11
IS  - 601555
PB  - Frontiers Media
CY  - Lausanne
ER  -