TY  - JOUR
A1  - Safari, Mojyan
A1  - Monsefi, Nadejda
A1  - Karimian-Tabrizi, Afsaneh
A1  - Miskovic, Alexandra
A1  - Linden, Arnaud van
A1  - Žáček, Pavel
A1  - Moritz, Anton
A1  - Walther, Thomas
A1  - Holubec, Tomas
T1  - Longer-term outcomes after bicuspid aortic valve repair in 142 patients
T2  - Journal of cardiac surgery
N2  - Background: The aim of this study was to evaluate the longer-term results of bicuspid aortic valve (BAV) repair with or without aortic root replacement. Methods: From 1999 to 2017, 142 patients with or without aortic root dilatation who underwent repair of a regurgitant BAV were included in the study. Ninety-four patients underwent isolated BAV repair (Group 1; median age 43 years) and 48 patients underwent valve-sparing aortic root replacement plus BAV repair (aortic valve reimplantation—Group 2; median age 48 years). Median clinical follow-up time was 5.9 years (range 0.5–15) in Group 1 and 3 years (range 0.5–16) in Group 2, respectively. Results: In-hospital mortality was 1% in Group 1, and 2% in Group 2 (p = .6). The 5- and 10-year survival was 93 ± 2.9% and 81 ± 5.8% in Group 1 and 96 ± 3.1% and 96 ± 3.1% in Group 2, respectively (p = .31). Eleven patients of Group 1 (1.7%/patient-year) and five patients of Group 2 (2.2%/patient-year) underwent reoperation of the aortic valve (p = .5). The 5- and 10-year freedom from reoperation were 93.0 ± 2.1% and 77.1 ± 7.1% in Group 1 and 93.0 ± 5.0% and 76.7 ± 9.6% in Group 2 (p = .83), respectively. At the latest follow-up, only two patients of Group 1 and 1 patient of Group 2 had AV regurgitation = 2° (p = .7). The cumulative linearized incidence of all valve-related complications (bleeding, stroke, endocarditis, and reoperation) was 2.9%/patient-year in Group 1% and 4%/patient-year in Group 2, respectively (p = .6). Conclusions: Isolated BAV repair and combined aortic valve reimplantation plus BAV repair provide good clinical longer-term outcomes with relatively low reoperation rate and durable valve function.
KW  - aortic root replacement
KW  - aortic valve repair
KW  - aortic valve-sparing
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64077
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-640771
SN  - 1540-8191
N1  - Open access funding enabled and organized by Projekt DEAL.
N1  - The study was supported by the Grant Agency of Charles University Progress Q40/4.
VL  - 36
IS  - 12
SP  - 4645
EP  - 4651
PB  - Wiley-Blackwell
CY  - Oxford
ER  -