TY  - INPR
A1  - Baltruschat, Lothar Gunnar
A1  - Tavosanis, Gaia
A1  - Cuntz, Hermann
T1  - A developmental stretch-and-fill process that optimises dendritic wiring
T2  - bioRxiv
N2  - The way in which dendrites spread within neural tissue determines the resulting circuit connectivity and computation. However, a general theory describing the dynamics of this growth process does not exist. Here we obtain the first time-lapse reconstructions of neurons in living fly larvae over the entirety of their developmental stages. We show that these neurons expand in a remarkably regular stretching process that conserves their shape. Newly available space is filled optimally, a direct consequence of constraining the total amount of dendritic cable. We derive a mathematical model that predicts one time point from the previous and use this model to predict dendrite morphology of other cell types and species. In summary, we formulate a novel theory of dendrite growth based on detailed developmental experimental data that optimises wiring and space filling and serves as a basis to better understand aspects of coverage and connectivity for neural circuit formation.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72787
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-727879
IS  - 2020.07.07.191064
ER  -