TY - JOUR A1 - Mertes, Bernardo A1 - Gödde, Sybille A1 - Piorkowski, Michael A1 - Kramer, Guido A1 - Müller, Ulrich Alfons A1 - Kuniß, Nadine T1 - Successful treatment with bedtime basal insulin added to metformin without weight gain or hypoglycaemia over three years T2 - Journal of Clinical Medicine N2 - The aim of this observational study was to follow-up patients with bedtime basal insulin (NPH insulin) added to metformin. In 285 patients with type 2 diabetes, a therapy with bedtime basal insulin added to metformin was started due to failure to achieve a glycaemic goal. Up until July 2019, 272 patients (95.4%) were followed-up (59.5 y, 92.6 kg, diabetes duration 6.6 y, HbA1c 8.4%/68.6 mmol/mol). HbA1c decreased by −1.2% and bodyweight by −1.7 kg after a duration of 31.7 ± 29.1 (range 2–133) months. Severe hypoglycaemia did not occur. In 144/272 patients (52.9%), the therapeutic goal for HbA1c was achieved over 32.7 months. In 69/272 patients (25.4%), the HbA1c target was achieved over 25.0 months (afterwards, therapy with basal insulin was discontinued because HbA1c was under target). In 36/272 patients (13.2%), the HbA1c goal was achieved until the submission of this manuscript (mean duration of treatment 57.4 ± 28.2 (range 13–121) months). Over 90% of patients with type 2 diabetes and failure of metformin reached their HbA1c goal with additional basal insulin at bedtime over several years in association with a reduction of bodyweight and without any event of severe hypoglycaemia. KW - basal insulin KW - NPH insulin KW - hypoglycaemia KW - metformin Y1 - 2020 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54369 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-543698 SN - 2077-0383 N1 - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited VL - 9 IS - 4, Art. 1153 SP - 1 EP - 12 PB - MDPI CY - Basel ER -