TY  - JOUR
A1  - Randall, Joshua C.
A1  - Winkler, Thomas W.
A1  - Kutalik, Zoltán
A1  - I. Berndt, Sonja
A1  - Jackson, Anne U.
A1  - Monda, Keri L.
A1  - Kilpeläinen, Tuomas O.
A1  - Esko, Tõnu
A1  - Mägi, Reedik
A1  - Li, Shengxu
A1  - Workalemahu, Tsegaselassie
A1  - Feitosa, Mary F.
A1  - Croteau-Chonka, Damien C.
A1  - Day, Felix R.
A1  - Fall, Tove
A1  - Ferreira, Teresa
A1  - Gustafsson, Stefan
A1  - Locke, Adam E.
A1  - Mathieson, Iain
A1  - Scherag, André
A1  - Vedantam, Sailaja
A1  - Wood, Andrew R.
A1  - Liang, Liming
A1  - Steinthorsdottir, Valgerdur
A1  - Thorleifsson, Gudmar
A1  - Dermitzakis, Emmanouil T.
A1  - Dimas, Antigone S.
A1  - Karpe, Fredrik
A1  - Min, Josine L.
A1  - Nicholson, George
A1  - Clegg, Deborah J.
A1  - Person, Thomas
A1  - Krohn, Jon P.
A1  - Bauer, Sabrina
A1  - Buechler, Christa
A1  - Eisinger, Kristina
A1  - Bonnefond, Amélie
A1  - Froguel, Philippe
A1  - Hottenga, Jouke-Jan
A1  - Prokopenko, Inga
A1  - Waite, Lindsay L.
A1  - Harris, Tamara B.
A1  - Smith, Albert Vernon
A1  - Shuldiner, Alan R.
A1  - McArdle, Wendy L.
A1  - Caulfield, Mark J.
A1  - Munroe, Patricia B.
A1  - Grönberg, Henrik
A1  - Chen, Yii-Der Ida
A1  - Li, Guo
A1  - Beckmann, Jacques S.
A1  - Johnson, Toby
A1  - Thorsteinsdottir, Unnur
A1  - Teder-Laving, Maris
A1  - Khaw, Kay-Tee
A1  - Wareham, Nicholas J.
A1  - Zhao, Jing Hua
A1  - Amin, Najaf
A1  - Oostra, Ben A.
A1  - Kraja, Aldi T.
A1  - Province, Michael A.
A1  - Cupples, L. Adrienne
A1  - Heard-Costa, Nancy L.
A1  - Kaprio, Jaakko
A1  - Ripatti, Samuli
A1  - Surakka, Ida
A1  - Collins, Francis S.
A1  - Saramies, Jouko
A1  - Tuomilehto, Jaakko
A1  - Jula, Antti
A1  - Salomaa, Veikko
A1  - Erdmann, Jeanette
A1  - Hengstenberg, Christian
A1  - Loley, Christina
A1  - Schunkert, Heribert
A1  - Lamina, Claudia
A1  - Wichmann, Heinz Erich
A1  - Albrecht, Eva
A1  - Gieger, Christian
A1  - Hicks, Andrew A.
A1  - Johansson, Åsa
A1  - Pramstaller, Peter P.
A1  - Kathiresan, Sekar
A1  - Speliotes, Elizabeth K.
A1  - Penninx, Brenda W. J. H.
A1  - Hartikainen, Anna-Liisa
A1  - Jarvelin, Marjo-Riitta
A1  - Gyllensten, Ulf
A1  - Boomsma, Dorret I.
A1  - Campbell, Harry
A1  - Wilson, James F.
A1  - Chanock, Stephen J.
A1  - Farrall, Martin
A1  - Goel, Anuj
A1  - Medina-Gomez, Carolina
A1  - Rivadeneira, Fernando
A1  - Estrada, Karol
A1  - Uitterlinden, André G.
A1  - Hofman, Albert
A1  - Zillikens, M. Carola
A1  - Heijer, Martin den
A1  - Kiemeney, Lambertus Adrianus
A1  - Maschio, Andrea
A1  - Hall, Per
A1  - Tyrer, Jonathan
A1  - Teumer, Alexander
A1  - Völzke, Henry
A1  - Kovacs, Peter
A1  - Tönjes, Anke
A1  - Mangino, Massimo
A1  - Spector, Tim D.
A1  - Hayward, Caroline
A1  - Rudan, Igor
A1  - Hall, Alistair S.
A1  - Samani, Nilesh J.
A1  - Attwood, Antony Paul
A1  - Sambrook, Jennifer G.
A1  - Hung, Joseph
A1  - Palmer, Lyle J.
A1  - Lokki, Marja-Liisa
A1  - Sinisalo, Juha
A1  - Boucher, Gabrielle
A1  - Huikuri, Heikki
A1  - Lorentzon, Mattias
A1  - Ohlsson, Claes
A1  - Eklund, Niina
A1  - Eriksson, Johan G.
A1  - Barlassina, Cristina
A1  - Rivolta, Carlo
A1  - Nolte, Ilja M.
A1  - Snieder, Harold
A1  - Klauw, Melanie M. van der
A1  - Vliet-Ostaptchouk, Jana V. van
A1  - Gejman, Pablo V.
A1  - Shi, Jianxin
A1  - Jacobs, Kevin B.
A1  - Wang, Zhaoming
A1  - Bakker, Stephan J. L.
A1  - Mateo Leach, Irene
A1  - Navis, Gerjan
A1  - Harst, Pim van der
A1  - Martin, Nicholas Gordon
A1  - Medland, Sarah E.
A1  - Montgomery, Grant W.
A1  - Yang, Jian
A1  - Chasman, Daniel I.
A1  - Ridker, Paul M.
A1  - Rose, Lynda M.
A1  - Lehtimäki, Terho
A1  - Raitakari, Olli
A1  - Absher, Devin
A1  - Iribarren, Carlos
A1  - Basart, Hanneke
A1  - Hovingh, Kees G.
A1  - Hyppönen, Elina
A1  - Power, Chris
A1  - Power, Chris
A1  - Anderson, Denise
A1  - Beilby, John P.
A1  - Hui, Jennie
A1  - Jolley, Jennifer
A1  - Sager, Hendrik
A1  - Bornstein, Stefan R.
A1  - Schwarz, Peter E. H.
A1  - Kristiansson, Kati
A1  - Perola, Markus
A1  - Lindström, Jaana
A1  - Swift, Amy J.
A1  - Uusitupa, Matti
A1  - Atalay, Mustafa
A1  - Lakka, Timo A.
A1  - Rauramaa, Rainer
A1  - Bolton, Jennifer L.
A1  - Fowkes, Gerry
A1  - Fraser, Ross M.
A1  - Price, Jackie F.
A1  - Fischer, Krista
A1  - Krjutškov, Kaarel
A1  - Metspalu, Andres
A1  - Mihailov, Evelin
A1  - Langenberg, Claudia
A1  - Luan, Jian'an
A1  - Ong, Ken K.
A1  - Chines, Peter S.
A1  - Keinanen-Kiukaanniemi, Sirkka M.
A1  - Saaristo, Timo E.
A1  - Edkins, Sarah
A1  - Franks, Paul W.
A1  - Hallmans, Göran
A1  - Shungin, Dmitry
A1  - Morris, Andrew David
A1  - Palmer, Colin N. A.
A1  - Erbel, Raimund
A1  - Moebus, Susanne
A1  - Nöthen, Markus Maria
A1  - Pechlivanis, Sonali
A1  - Hveem, Kristian
A1  - Narisu, Narisu
A1  - Hamsten, Anders
A1  - Humphries, Steve E.
A1  - Strawbridge, Rona J.
A1  - Tremoli, Elena
A1  - Grallert, Harald
A1  - Thorand, Barbara
A1  - Illig, Thomas
A1  - Koenig, Wolfgang
A1  - Müller-Nurasyid, Martina
A1  - Peters, Annette
A1  - Böhm, Bernhard O.
A1  - Kleber, Marcus E.
A1  - März, Winfried
A1  - Winkelmann, Bernhard R.
A1  - Kuusisto, Johanna
A1  - Laakso, Markku
A1  - Arveiler, Dominique
A1  - Cesana, Giancarlo
A1  - Kuulasmaa, Kari
A1  - Virtamo, Jarmo
A1  - Yarnell, John W. G.
A1  - Kuh, Diana
A1  - Wong, Andrew
A1  - Lind, Lars
A1  - Faire, Ulf de
A1  - Gigante, Bruna
A1  - Magnusson, Patrik K. E.
A1  - Pedersen, Nancy L.
A1  - Dedoussis, George
A1  - Dimitriou, Maria
A1  - Kolovou, Genovefa
A1  - Kanoni, Stavroula
A1  - Stirrups, Kathleen
A1  - Bonnycastle, Lori L.
A1  - Njølstad, Inger
A1  - Wilsgaard, Tom
A1  - Ganna, Andrea
A1  - Rehnberg, Emil
A1  - Hingorani, Aroon
A1  - Kivimaki, Mika
A1  - Kumari, Meena
A1  - Assimes, Themistocles L.
A1  - Barroso, Inês
A1  - Boehnke, Michael
A1  - Borecki, Ingrid B.
A1  - Deloukas, Panos
A1  - Fox, Caroline S.
A1  - Frayling, Timothy
A1  - Groop, Leif C.
A1  - Haritunians, Talin
A1  - Hunter, David
A1  - Ingelsson, Erik
A1  - Kaplan, Robert
A1  - Mohlke, Karen L.
A1  - North, Kari E.
A1  - Lindgren, Cecilia M.
A1  - Qi, Lu
A1  - Loos, Ruth J. F.
A1  - Heid, Iris M.
A1  - Hirschhorn, Joel N.
A1  - McCarthy, Mark I.
A1  - Abecasis, Gonçalo R.
A1  - Stefansson, Kari
A1  - Strachan, David P.
A1  - Schlessinger, David
A1  - O'Connell, Jeffrey R.
A1  - Duijn, Cornelia M. van
T1  - Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
T2  - PLoS Genetics
N2  - Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30105
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-301058
SN  - 1553-7404
SN  - 1553-7390
N1  - This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
VL  - 9
IS  - (6):e1003500
PB  - Public Library of Science
CY  - San Francisco, Calif.
ER  -