TY  - INPR
A1  - Kumral, Deniz
A1  - Cesnaite, Elena
A1  - Beyer, Frauke
A1  - Hofmann, Simon M.
A1  - Hensch, Tilman
A1  - Sander, Christian
A1  - Hegerl, Ulrich
A1  - Haufe, Stefan
A1  - Villringer, Arno
A1  - Witte, A. Veronica
A1  - Nikulin, Vadim
T1  - Relationship between regional white matter hyperintensities and alpha oscillations in older adults
T2  - bioRxiv
N2  - White matter hyperintensities (WMHs) in the cerebral white matter and attenuation of alpha oscillations (AO; 7–13 Hz) occur with the advancing age. However, a crucial question remains, whether changes in AO relate to aging per se or they rather reflect the impact of age-related neuropathology like WMHs. In this study, using a large cohort (N=907) of elderly participants (60-80 years), we assessed relative alpha power (AP), individual alpha peak frequency (IAPF) and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that higher prevalence of WMHs in the superior and posterior corona radiata was related to elevated relative AP, with strongest correlations in the bilateral occipital cortex, even after controlling for potential confounding factors. In contrast, we observed no significant relation of probability of WMH occurrence with IAPF and LRTC. We argue that the WMH-associated increase of AP reflects generalized and likely compensatory changes of AO leading to a larger number of synchronously recruited neurons.
KW  - EEG
KW  - MRI
KW  - white matter hyperintensity
KW  - aging
KW  - alpha power
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83577
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-835773
UR  - https://www.biorxiv.org/content/10.1101/2020.09.04.283200v2
IS  - 2020.09.04.283200 Version 2
PB  - bioRxiv
ER  -