TY  - INPR
A1  - Kumral, Deniz
A1  - Cesnaite, Elena
A1  - Beyer, Frauke
A1  - Hofmann, Simon M.
A1  - Hensch, Tilman
A1  - Sander, Christian
A1  - Hegerl, Ulrich
A1  - Haufe, Stefan
A1  - Villringer, Arno
A1  - Witte, A. Veronica
A1  - Nikulin, Vadim
T1  - Relationship between regional white matter hyperintensities and alpha oscillations in older adults
T2  - bioRxiv
N2  - Aging is associated with increased white matter hyperintensities (WMHs) and with the alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. Although an increase in alpha oscillations due to WMH can have a compensatory nature, we rather suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources.
KW  - EEG
KW  - MRI
KW  - white matter hyperintensity
KW  - aging
KW  - alpha power
KW  - resting-state
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72890
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-728903
UR  - https://www.biorxiv.org/content/10.1101/2020.09.04.283200v3
IS  - 2020.09.04.283200 Version 3
PB  - bioRxiv
ER  -