TY  - JOUR
A1  - Stefanini, Francisco R.
A1  - Badaro, Emmerson
A1  - Falabella, Paulo
A1  - Koss, Michael Janusz
A1  - Farah, Michel Eid
A1  - Maia, Maurício
T1  - Anti-VEGF for the management of diabetic macular edema
T2  - Journal of Immunology Research
N2  - Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoagulation has been the standard treatment for this condition reducing the risk of moderate visual loss by approximately 50%. The role of vascular endothelial growth factor (VEGF) in DR and DME pathogenesis has been demonstrated in recent studies. This review addresses and summarizes data from the clinical trials that investigated anti-VEGF for the management of DME and evaluates their impact on clinical practice. The literature searches were conducted between August and October 2013 in PubMed and Cochrane Library with no date restrictions and went through the most relevant studies on pegaptanib, ranibizumab, bevacizumab, and aflibercept for the management of DME. The efficacy and safety of intravitreal anti-VEGF as therapy for DME have recently been proved by various clinical trials providing significantly positive visual and anatomical results. Regarding clinical practice, those outcomes have placed intravitreal injection of anti-VEGF as an option that must be considered for the treatment of DME.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50516
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-505162
SN  - 2314-8861
SN  - 2314-7156
N1  - Copyright © 2014 Francisco Rosa Stefanini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2014
IS  - Art. 632307
SP  - 1
EP  - 8
PB  - Hindawi
CY  - New York, NY
ER  -