TY  - JOUR
A1  - Hector, Andreas
A1  - Kormann, Michael
A1  - Mack, Ines
A1  - Latzin, Philipp
A1  - Casaulta, Carmen
A1  - Kieninger, Elisabeth
A1  - Zhou, Zhe
A1  - Yildirim, Ali Önder
A1  - Bohla, Alexander
A1  - Rieber, Nikolaus
A1  - Kappler, Matthias
A1  - Koller, Barbara
A1  - Eber, Ernst
A1  - Eickmeier, Olaf
A1  - Zielen, Stefan
A1  - Eickelberg, Oliver
A1  - Griese, Matthias
A1  - Mall, Marcus A.
A1  - Hartl, Dominik
T1  - The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease
T2  - PLoS One
N2  - The chitinase-like protein YKL-40 was found to be increased in patients with severe asthma and chronic obstructive pulmonary disease (COPD), two disease conditions featuring neutrophilic infiltrates. Based on these studies and a previous report indicating that neutrophils secrete YKL-40, we hypothesized that YKL-40 plays a key role in cystic fibrosis (CF) lung disease, a prototypic neutrophilic disease. The aim of this study was (i) to analyze YKL-40 levels in human and murine CF lung disease and (ii) to investigate whether YKL-40 single-nucleotide polymorphisms (SNPs) modulate CF lung disease severity. YKL-40 protein levels were quantified in serum and sputum supernatants from CF patients and control individuals. Levels of the murine homologue BRP-39 were analyzed in airway fluids from CF-like βENaC-Tg mice. YKL-40SNPs were analyzed in CF patients. YKL-40 levels were increased in sputum supernatants and in serum from CF patients compared to healthy control individuals. Within CF patients, YKL-40 levels were higher in sputum than in serum. BRP-39 levels were increased in airways fluids from βENaC-Tg mice compared to wild-type littermates. In both CF patients and βENaC-Tg mice, YKL-40/BRP-39 airway levels correlated with the severity of pulmonary obstruction. Two YKL-40 SNPs (rs871799 and rs880633) were found to modulate age-adjusted lung function in CF patients. YKL-40/BRP-39 levelsare increased in human and murine CF airway fluids, correlate with pulmonary function and modulate CF lung disease severity genetically. These findings suggest YKL-40 as a potential biomarker in CF lung disease.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22769
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-227692
SN  - 1932-6203
N1  - Copyright: © 2011 Hector et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 6
IS  - 9: e24399
SP  - 1
EP  - 6
PB  - PLoS
CY  - Lawrence, Kan.
ER  -