TY  - JOUR
A1  - Raafat, Karim
A1  - Wurglics, Mario
T1  - Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity
T2  - Journal of traditional and complementary medicine
N2  - The anticonvulsant potential of Ficus carica methanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG). 1H, 13C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile. Keywords: Ficus carica, Moraceae, Nano-ESI MS, MALDI MS, Intracerebroventricular, Anticonvulsant activity.
KW  - Ficus carica
KW  - Moraceae
KW  - Nano-ESI MS
KW  - MALDI MS
KW  - Intracerebroventricular
KW  - Anticonvulsant activity
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54496
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-544961
SN  - 2225-4110
N1  - © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 9
IS  - 4
SP  - 263
EP  - 270
PB  - Medknow Publ.
CY  - Mumbai
ER  -