TY  - JOUR
A1  - Koch, Christine
A1  - Schwing, Anna M.
A1  - Herrmann, Eva
A1  - Borner, Markus
A1  - Díaz-Rubio, Eduardo
A1  - Dotan, Efrat
A1  - Feliu, Jaime
A1  - Okita, Natsuko
A1  - Souglakos, John
A1  - Arkenau, Hendrik-Tobias
A1  - Porschen, Rainer
A1  - Koopman, Miriam
A1  - Punt, Cornelis J. A.
A1  - Gramont, Aimery de
A1  - Tournigand, Christophe
A1  - Zeuzem, Stefan
A1  - Trojan, Jörg
T1  - Bevacizumab-based first-line chemotherapy in elderly patients with metastatic colorectal cancer : an individual patient data based meta-analysis
T2  - OncoTarget
N2  - Background: The aim of this meta-analysis was to evaluate efficacy and safety of first-line chemotherapy with or without a monoclonal antibody in elderly patients ( ≥ 70 years) with metastatic colorectal cancer (mCRC), since they are frequently underrepresented in clinical trials.
Results: Individual data from 10 studies were included. From a total of 3271 patients, 604 patients (18%) were ≥ 70 years (median 73 years, range 70–88). Of these, 335 patients were treated with a bevacizumab-based first-line regimen and 265 were treated with chemotherapy only. The median PFS was 8.2 vs. 6.5 months and the median OS was 16.7 vs. 13.0 months in patients treated with and without bevacizumab, respectively. The safety profile of bevacizumab in combination with first-line chemotherapy did not differ from published clinical trials.
Materials and Methods: PubMed and Cochrane Library searches were performed on 29 April 2013 and studies published to this date were included. Authors were contacted to request progression-free survival (PFS), overall survival (OS) data, patient data on treatment regimens, age, sex and potential signs of toxicity in patients ≥ 70 years of age.
Conclusions: This meta-analysis suggests that the addition of bevacizumab to standard first-line chemotherapy improves clinical outcome in elderly patients with mCRC and is well tolerated.
KW  - metastatic colorectal cancer
KW  - elderly
KW  - first-line chemotherapy
KW  - bevacizumab
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46384
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463848
SN  - 1949-2553
N1  - Copyright: Koch et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - 12
SP  - 10272
EP  - 10283
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -