TY  - JOUR
A1  - Mandel, Philipp
A1  - Höh, Robert Benedikt
A1  - Preißer, Felix Martin
A1  - Wenzel, Mike
A1  - Humke, Clara Julia
A1  - Welte, Maria-Noemi
A1  - Jerrentrup, Inga
A1  - Köllermann, Jens
A1  - Wild, Peter Johannes
A1  - Tilki, Derya
A1  - Haese, Alexander
A1  - Becker, Andreas
A1  - Roos, Frederik
A1  - Chun, Felix
A1  - Kluth, Luis
T1  - Influence of tumor burden on serum prostate-specific antigen in prostate cancer patients undergoing radical prostatectomy
T2  - Frontiers in Oncology
N2  - Objective: We aimed to assess the correlation between serum prostate-specific antigen (PSA) and tumor burden in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), because estimation of tumor burden is of high value, e.g., in men undergoing RP or with biochemical recurrence after RP. Patients and Methods: From January 2019 to June 2020, 179 consecutive PCa patients after RP with information on tumor and prostate weight were retrospectively identified from our prospective institutional RP database. Patients with preoperative systemic therapy (n=19), metastases (cM1, n=5), and locally progressed PCa (pT4 or pN1, n=50) were excluded from analyses. Histopathological features, including total weight of the prostate and specific tumor weight, were recorded by specialized uro-pathologists. Linear regression models were performed to evaluate the effect of PSA on tumor burden, measured by tumor weight after adjustment for patient and tumor characteristics. Results: Overall, median preoperative PSA was 7.0 ng/ml (interquartile range [IQR]: 5.41–10) and median age at surgery was 66 years (IQR: 61-71). Median prostate weight was 34 g (IQR: 26–46) and median tumor weight was 3.7 g (IQR: 1.8–7.1), respectively. In multivariable linear regression analysis after adjustment for patients and tumor characteristics, a significant, positive correlation could be detected between preoperative PSA and tumor weight (coefficient [coef.]: 0.37, CI: 0.15–0.6, p=0.001), indicating a robust increase in PSA of almost 0.4 ng/ml per 1g tumor weight. Conclusion: Preoperative PSA was significantly correlated with tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This might help to estimate both tumor burden before undergoing RP and in case of biochemical recurrence.
KW  - prostate cancer
KW  - prostate-specific antigen
KW  - PSA
KW  - tumor weight
KW  - radical prostatectomy
KW  - correlation
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62451
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-624517
SN  - 2234-943X
VL  - 11
IS  - art. 656444
SP  - 1
EP  - 5
PB  - Frontiers Media
CY  - Lausanne
ER  -