TY  - JOUR
A1  - Kempf, Kerstin
A1  - Röhling, Martin
A1  - Banzer, Winfried
A1  - Braumann, Klaus-Michael
A1  - Halle, Martin
A1  - McCarthy, David
A1  - Predel, Hans-Georg
A1  - Schenkenberger, Isabelle
A1  - Tan, Susanne
A1  - Toplak, Hermann
A1  - Berg, Aloys
A1  - Martin, Stephan
T1  - High-protein, low-glycaemic meal replacement decreases fasting insulin and inflammation markers - a 12-month subanalysis of the ACOORH trial
T2  - Nutrients
N2  - Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the international multicentre randomised controlled ACOORH (Almased Concept against Overweight and Obesity and Related Health Risk) trial, overweight or obese persons who meet the criteria for metabolic syndrome (n = 463) were randomised into two groups. Both groups received nutritional advice focusing on carbohydrate restriction and the use of telemonitoring devices. The intervention group substituted all three main meals per day in week 1, two meals per day in weeks 2–4, and one meal per day in weeks 5–26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline and after 1, 3, 6 and 12 months. All datasets providing insulin data (n = 446) were included in this predefined subanalysis. Significantly higher reductions in insulin (−3.3 ± 8.7 µU/mL vs. −1.6 ± 9.8 µU/mL), weight (−6.1 ± 5.2 kg vs. −3.2 ± 4.6 kg), and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and the highest amount of weight loss (−7.6 ± 4.9 kg) was observed in those participants with an insulin decrease > 2 µU/mL. These results underline the potential for meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin levels may serve as an indicator for adherence to carbohydrate restriction.
KW  - fasting insulin
KW  - lifestyle intervention
KW  - protein-rich
KW  - low-glycaemic meal replacement
KW  - low-carbohydrate
KW  - overweight
KW  - obesity
KW  - weight reduction
KW  - multicentre study
KW  - RCT
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62127
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621277
SN  - 2072-6643
N1  - The study was financially supported by the Almased-Wellness-GmbH. The funder had no influence on study design, data collection, data analysis, manuscript preparation, and/or publication decisions.
VL  - 13
IS  - 5, art. 1433
SP  - 1
EP  - 12
PB  - MDPI
CY  - Basel
ER  -