TY  - INPR
A1  - Rößler, Nina
A1  - Jungenitz, Tassilo
A1  - Sigler, Albrecht
A1  - Bird, Alexander D
A1  - Mittag, Martin
A1  - Rhee, Jeong Seop
A1  - Deller, Thomas
A1  - Cuntz, Hermann
A1  - Brose, Nils
A1  - Schwarzacher, Stephan
A1  - Jedlička, Peter
T1  - Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity and emerges early during adult neurogenesis
T2  - bioRxiv
N2  - Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity in vivo and CA1 pyramidal cells from Munc-13-1-Munc13-2 knockout mice with completely blocked synaptic transmission. Neither induction of extrinsic synaptic plasticity nor the blockage of presynaptic activity degrades the lognormal-like distribution but changes its mean, variance and skewness. The skewed distribution develops early in the life of the neuron. Our findings and their computational modelling support the idea that intrinsic synaptic plasticity is sufficient for the generation, while a combination of intrinsic and extrinsic synaptic plasticity maintains lognormal like distribution of spines.
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73179
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-731796
IS  - 2023.03.15.532740
ER  -