TY  - JOUR
A1  - Kim, Mia
A1  - Grimmig, Tanja
A1  - Grimm, Martin
A1  - Lazariotou, Maria
A1  - Meier, Eva
A1  - Rosenwald, Andreas
A1  - Tsaur, Igor
A1  - Blaheta, Roman A.
A1  - Heemann, Uwe
A1  - Germer, Christoph-Thomas
A1  - Waaga, Ana Maria da Silva Rosa
A1  - Gasser, Martin
T1  - Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer
T2  - PLoS One
N2  - Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC).
Methods and Findings: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival.
Conclusions: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28769
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-287690
SN  - 1932-6203
N1  - Copyright: (c) 2013 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 8
IS  - 1: e53630
PB  - PLoS
CY  - Lawrence, Kan.
ER  -