TY  - JOUR
A1  - Schmidt-Hieber, Martin
A1  - Silling, Gerda
A1  - Schalk, Enrico
A1  - Heinz, Werner
A1  - Panse, Jens
A1  - Penack, Olaf
A1  - Christopeit, Maximilian
A1  - Buchheidt, Dieter
A1  - Meyding-Lamadé, Uta
A1  - Hähnel, Stefan
A1  - Wolf, Hans-Heinrich
A1  - Ruhnke, Markus
A1  - Schwartz, Stefan
A1  - Maschmeyer, Georg
T1  - CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)
T2  - Annals of oncology
N2  - Infections of the central nervous system (CNS) are infrequently diagnosed in immunocompetent patients, but they do occur in a significant proportion of patients with hematological disorders. In particular, patients undergoing allogeneic hematopoietic stem-cell transplantation carry a high risk for CNS infections of up to 15%. Fungi and Toxoplasma gondii are the predominant causative agents. The diagnosis of CNS infections is based on neuroimaging, cerebrospinal fluid examination and biopsy of suspicious lesions in selected patients. However, identification of CNS infections in immunocompromised patients could represent a major challenge since metabolic disturbances, side-effects of antineoplastic or immunosuppressive drugs and CNS involvement of the underlying hematological disorder may mimic symptoms of a CNS infection. The prognosis of CNS infections is generally poor in these patients, albeit the introduction of novel substances (e.g. voriconazole) has improved the outcome in distinct patient subgroups. This guideline has been developed by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) with the contribution of a panel of 14 experts certified in internal medicine, hematology/oncology, infectious diseases, intensive care, neurology and neuroradiology. Grades of recommendation and levels of evidence were categorized by using novel criteria, as recently published by the European Society of Clinical Microbiology and Infectious Diseases.
KW  - guideline
KW  - central nervous system infection
KW  - immunocompromised patient
KW  - diagnosis
KW  - treatment
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45576
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-455766
SN  - 1569-8041
SN  - 0923-7534
N1  - © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/),
which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
VL  - 27
IS  - 7
SP  - 1207
EP  - 1225
PB  - Oxford Univ. Press
CY  - Oxford
ER  -