TY  - JOUR
A1  - Marggrander, Daniel Tobias
A1  - Koç-Günel, Sinem
A1  - Tekeli-Camcı, Nesrin
A1  - Martin, Simon
A1  - Golbach, Rejane
A1  - Wolf, Timo
T1  - Lung ultrasound effectively detects HIV-associated interstitial pulmonary disease
T2  - International Journal of Infectious Diseases
N2  - Objectives: To prospectively evaluate lung ultrasound in comparison with radiography and computed tomography (CT) for detecting HIV-related lung diseases.
Methods: Ultrasound examinations in HIV-positive patients were evaluated by three raters; available conventional imaging was evaluated by another rater. Results were compared with each other and the definite diagnosis. Interrater reliability was calculated for each finding.
Results: Eighty HIV-positive patients received lung ultrasound examinations; 74 received conventional imaging. The overall sensitivity was 97.5% for CT, 90.7% for ultrasound and 78.1% for radiography. The most common diagnoses were Pneumocystis jirovecii pneumonia (21 cases) and bacterial pneumonia (17 cases). The most frequent and sensitive ultrasonographic findings were interstitial abnormalities indicated by B-lines, independent of the aetiology. Interrater reliability was high for interstitial abnormalities (ICC=0.82). The interrater reliability for consolidations and effusion increased during the study (r=0.88 and r=0.37, respectively).
Conclusions: Ultrasound is a fast, reliable and sensitive point-of-care tool, particularly in detecting interstitial lung disease, which is common in HIV-associated illness. It does not effectively discriminate between different aetiologies. A longer learning period might be required to reliably identify consolidations and effusions.
KW  - AIDS
KW  - Pneumocystis jirovecii
KW  - Pneumonia
KW  - Sonography
KW  - Point of care
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77913
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-779137
SN  - 1201-9712
VL  - 111
SP  - 204
EP  - 210
PB  - Elsevier
CY  - Amsterdam
ER  -