TY  - JOUR
A1  - Benz, Alexander
A1  - Renné, Christoph
A1  - Maronde, Erik
A1  - Koch, Marko
A1  - Grabiec, Urszula
A1  - Kallendrusch, Sonja
A1  - Rengstl, Benjamin
A1  - Newrzela, Sebastian
A1  - Hartmann, Sylvia
A1  - Hansmann, Martin-Leo
A1  - Dehghani, Faramarz
T1  - Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma
T2  - PLoS One
N2  - Background: Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.
Design and Methods: We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated.
Results: A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells.
Conclusions: The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32884
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-328849
SN  - 1932-6203
N1  - Copyright: © 2013 Benz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 8
IS  - (12):e81675
PB  - PLoS
CY  - Lawrence, Kan.
ER  -