TY  - JOUR
A1  - Rezende Felipe, Flávia Figueiredo de
A1  - Schürmann, Christoph
A1  - Schütz, Susanne
A1  - Harenkamp, Sabine
A1  - Herrmann, Eva
A1  - Seimetz, Michael
A1  - Weißmann, Norbert
A1  - Schröder, Katrin
T1  - Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
T2  - Redox Biology
N2  - The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice.
KW  - Nox4
KW  - Aging
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43242
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-432422
SN  - 2213-2317
N1  - © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
VL  - 11
SP  - 312
EP  - 314
PB  - Elsevier
CY  - Amsterdam [u. a.]
ER  -