TY  - JOUR
A1  - Turi, Georg
A1  - Gotthardt, Sascha
A1  - Singer, Wolf
A1  - Anh Vuong, The
A1  - Munk, Matthias Hans Joachim
A1  - Wibral, Michael
T1  - Quantifying additive evoked contributions to the event-related potential
T2  - NeuroImage
N2  - Event-related potentials (ERPs) are widely used in basic neuroscience and in clinical diagnostic procedures. In contrast, neurophysiological insights from ERPs have been limited, as several different mechanisms lead to ERPs. Apart from stereotypically repeated responses (additive evoked responses), these mechanisms are asymmetric amplitude modulations and phase-resetting of ongoing oscillatory activity. Therefore, a method is needed that differentiates between these mechanisms and moreover quantifies the stability of a response. We propose a constrained subspace independent component analysis that exploits the multivariate information present in the all-to-all relationship of recordings over trials. Our method identifies additive evoked activity and quantifies its stability over trials. We evaluate identification performance for biologically plausible simulation data and two neurophysiological test cases: Local field potential (LFP) recordings from a visuo-motor-integration task in the awake behaving macaque and magnetoencephalography (MEG) recordings of steady-state visual evoked fields (SSVEFs). In the LFPs we find additive evoked response contributions in visual areas V2/4 but not in primary motor cortex A4, although visually triggered ERPs were also observed in area A4. MEG-SSVEFs were mainly created by additive evoked response contributions. Our results demonstrate that the identification of additive evoked response contributions is possible both in invasive and in non-invasive electrophysiological recordings.
KW  - Event-related potential
KW  - Local field potential
KW  - Electroencephalography
KW  - Phase-reset
KW  - Multiset independent component analysis
KW  - Generalized procrustes analysis
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76655
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-766553
SN  - 1053-8119
VL  - 59.2012
IS  - 3
SP  - 2607
EP  - 2624
PB  - Elsevier
CY  - Amsterdam
ER  -