TY  - INPR
A1  - Bojkova, Denisa
A1  - Rothenburger, Tamara
A1  - Ciesek, Sandra
A1  - Wass, Mark N.
A1  - Michaelis, Martin
A1  - Cinatl, Jindrich
T1  - SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment
T2  - bioRxiv
N2  - Recently, we have shown that SARS-CoV-2 Omicron virus isolates are less effective at inhibiting the host cell interferon response than Delta viruses. Here, we present further evidence that reduced interferon-antagonising activity explains at least in part why Omicron variant infections are inherently less severe than infections with other SARS-CoV-2 variants. Most importantly, we here also show that Omicron variant viruses display enhanced sensitivity to interferon treatment, which makes interferons promising therapy candidates for Omicron patients, in particular in combination with other antiviral agents.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73006
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-730065
IS  - 2022.01.20.477067
ER  -