TY  - JOUR
A1  - Grkovic, Tanja
A1  - Blees, Johanna S.
A1  - Bayer, Magdalena M.
A1  - Colburn, Nancy H.
A1  - Thomas, Cheryl L.
A1  - Henrich, Curtis J.
A1  - Peach, Megan L.
A1  - McMahon, James B.
A1  - Schmid, Tobias
A1  - Gustafson, Kirk R.
T1  - Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4
T2  - Marine drugs
N2  - A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of these tricyclic guanidine alkaloids were established from extensive spectroscopic analyses. Compounds 1 and 2 inhibited cellular degradation of PDCD4 with EC50 values of 1.8 μg/mL and 2.8 μg/mL, respectively. Mirabilin G (1) and netamine M (2) are the first marine natural products reported to stabilize PDCD4 under tumor promoting conditions.
KW  - natural product
KW  - guanidine alkaloid
KW  - PDCD4
KW  - tumor suppressor
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37243
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-372435
SN  - 1660-3397
N1  - Copyright © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 12
IS  - 8
SP  - 4593
EP  - 4601
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -