TY  - JOUR
A1  - Hartwig, Maite
A1  - Zander, Axel R.
A1  - Haferlach, Torsten
A1  - Fehse, Boris
A1  - Kröger, Nicolaus
A1  - Bacher, Ulrike
T1  - Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies
T2  - Cellular Therapy and Transplantation
N2  - The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder. Therefore, an optimized indication for SCT in AML first requires the determination of the individual relapse risk based on diverse chromosomal and molecular prognosis-defining aberrations. A broad panel of diagnostic methods is needed to allow such subclassification and prognostic stratification: cytomorphology, cytogenetics, molecular genetics, and immunophenotyping by multiparameter flow cytometry. These methods should not be seen as isolated techniques but as parts of an integral network with hierarchies and interactions. Examples for a poor risk constellation as a clear indication for allogeneic SCT are provided by anomalies of chromosome 7, complex aberrations, or FLT3-length mutations. In contrast, the favorable reciprocal translocations such as the t(15;17)/PML-RARA or t(8;21)/AML1-ETO are not indications for SCT in first remission due to the rather good prognosis after standard therapy. Further, the indication for SCT should include the results of minimal residual disease (MRD) diagnostics by polymerase chain reaction (PCR) or flow cytometry. New aspects for a safe and fast risk stratification as basis for an optimized indication for SCT in AML might be provided by novel technologies such as microarray-based gene expression profiling. Keywords: Acute Myeloid Leukemia (AML), Allogeneic Stem Cell Transplantation (SCT), Indication, Cytogenetics, Polymerase Chain Reaction (PCR)
KW  - Acute Myeloid Leukemia (AML)
KW  - Allogeneic Stem Cell Transplantation (SCT)
KW  - Indication
KW  - Cytogenetics
KW  - Polymerase Chain Reaction (PCR)
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22487
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-113040
SN  - 1867-416X
SN  - 1866-8836
N1  - © The Authors. This article is provided under the following license: Creative Commons Attribution-Share Alike 2.0 Germany. Please cite this article as follows: Hartwig M, Zander AR, Haferlach T, Fehse B, Kröger N, Bacher U. Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies. Cell Ther Transplant. 2008;1:e.2008-05-26-001-en. doi:10.3205/ctt2008-05-26-001-en
VL  - 1
IS  - 1
SP  - 18
EP  - 24
PB  - Univ. Medical Center, Clinic for Stem Cell Transplantation, Center of Oncology
CY  - Hamburg
ER  -