TY  - INPR
A1  - Baumeister, Sarah
A1  - Mößnang, Carolin Ulrike
A1  - Bast, Nico
A1  - Hohmann, Sarah
A1  - Tillmann, Julian
A1  - Goyard, David
A1  - Charman, Tony
A1  - Ambrosino, Sara
A1  - Baron-Cohen, Simon
A1  - Beckmann, Christian F.
A1  - Bölte, Sven
A1  - Bourgeron, Thomas
A1  - Rausch, Annika
A1  - Crawley, Daisy
A1  - Dell'Acqua, Flavio
A1  - Dumas, Guillaume
A1  - Durston, Sarah
A1  - Ecker, Christine
A1  - Floris, Dorothea L.
A1  - Frouin, Vincent
A1  - Hayward, Hannah
A1  - Holt, Rosemary
A1  - Johnson, Mark H.
A1  - Jones, Emily J. H.
A1  - Lai, Meng-Chuan
A1  - Lombardo, Michael V.
A1  - Mason, Luke
A1  - Oldehinkel, Marianne
A1  - Persico, Tony
A1  - San José Cáceres, Antonia
A1  - Wolfers, Thomas
A1  - Spooren, Willibrordus Philippus Johannes Maria
A1  - Loth, Eva
A1  - Murphy, Declan G. M.
A1  - Buitelaar, Jan K.
A1  - Tost, Heike
A1  - Meyer-Lindenberg, Andreas
A1  - Banaschewski, Tobias
A1  - Brandeis, Daniel
T1  - Attenuated anticipation of social and monetary rewards in autism spectrum disorders
T2  - bioRxiv
N2  - Background Reward processing has been proposed to underpin atypical social behavior, a core feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social rewards in ASD. Utilizing a large sample, we aimed to assess altered reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD.
Methods Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.5 years) and 181 typically developing (TD) participants (7.6-30.8 years).
Results Across social and monetary reward anticipation, whole-brain analyses (p<0.05, family-wise error-corrected) showed hypoactivation of the right ventral striatum (VS) in ASD. Further, region of interest (ROI) analysis across both reward types yielded hypoactivation in ASD in both the left and right VS. Across delivery of social and monetary reward, hyperactivation of the VS in individuals with ASD did not survive correction for multiple comparisons. Reward type by diagnostic group interactions, and a dimensional analysis of autism trait scores were not significant during anticipation or delivery. Levels of attention-deficit/hyperactivity disorder (ADHD) symptoms did not affect reward processing in ASD.
Conclusions Our results do not support current theories linking atypical social interaction in ASD to specific alterations in processing of social rewards. Instead, they point towards a generalized hypoactivity of VS in ASD during anticipation of both social and monetary rewards. We suggest that this indicates attenuated subjective reward value in ASD independent of social content and ADHD symptoms.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72785
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-727854
IS  - 2020.07.06.186650
ER  -