TY  - JOUR
A1  - Varga, Julia
A1  - Oliveira, Tiago de
A1  - Greten, Florian
T1  - The architect who never sleeps : tumor-induced plasticity
T2  - FEBS letters
N2  - Tumor cell plasticity is an event that has been observed in several malignancies. In fact, most of the solid tumors are characterized by cellular heterogeneity and undergo constant changes as the tumor develops. The increased plasticity displayed by these cells allows them to acquire additional properties, enabling epithelial-mesenchymal transitions, dedifferentiation and the acquisition of stem cell-like properties. Here we discuss the particular importance of an inflammatory microenvironment for the bidirectional control of cellular plasticity and the potential for therapeutic intervention.
KW  - Cancer
KW  - Cell plasticity
KW  - Tumor microenvironment
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/35262
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-352626
SN  - 1873-3468
SN  - 0014-5793
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
VL  - 588
IS  - 15
SP  - 2422
EP  - 2427
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -