TY  - JOUR
A1  - Zemrak, Filip
A1  - Raisi-Estabragh, Zahra
A1  - Khanji, Mohammed Y.
A1  - Mohiddin, Saidi A.
A1  - Bruder, Oliver
A1  - Wagner, Anja
A1  - Lombardi, Massimo
A1  - Schwitter, Juerg
A1  - Rossum, Albert C. van
A1  - Pilz, Günter
A1  - Nothnagel, Detlev
A1  - Steen, Henning
A1  - Nagel, Eike
A1  - Prasad, Sanjay K.
A1  - Deluigi, Christina Christina
A1  - Dill, Thorsten
A1  - Frank, Herbert
A1  - Schneider, Steffen
A1  - Mahrholdt, Heiko
A1  - Petersen, Steffen Erhard
T1  - Left ventricular hypertrabeculation is not associated with cardiovascular morbity or mortality: insights from the Eurocmr registry
T2  - Frontiers in Cardiovascular Medicine
N2  - Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry.
Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3.
Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.
KW  - left ventricular non-compaction
KW  - left ventricular trabeculation
KW  - cardiomyopathy
KW  - cardiac magnetic
KW  - resonance
KW  - mortality
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57206
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-572060
SN  - 2297-055X
VL  - 11
IS  - Article 158
PB  - Frontiers Media
CY  - Lausanne
ER  -