TY - JOUR A1 - Buckel, Iris A1 - Andernach, Lars A1 - Schüfer, Anja A1 - Piepenbring, Meike A1 - Opatz, Till A1 - Thines, Eckhard T1 - Phytotoxic dioxolanones are potential virulence factors in the infection process of Guignardia bidwellii T2 - Scientific reports N2 - Phytotoxic dioxolanones from Guignardia bidwellii can be described as potential virulence factors which cause the formation of lesions upon an infection by G. bidwellii. The toxin guignardic acid was found in planta of G. bidwellii-infected Vitis vinifera leaves, whereas no phytotoxic dioxolanones were detected in uninfected leaf material. Secondary metabolism analyses of further phytopathogenic fungi from the genus Guignardia led to the observation that all species investigated can produce the phytotoxins known from G. bidwellii. In addition to these studies, it was demonstrated that phenguignardic acid is biosynthetically derived from two molecules of phenylalanine and that phenylalanine is a key precursor in the biosynthesis of the two other phytotoxins – alaguignardic acid and guignardic acid. KW - Environmental microbiology KW - Natural product synthesis Y1 - 2017 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48838 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488386 SN - 2045-2322 N1 - Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. VL - 7 IS - 1, Art. 8926 SP - 1 EP - 7 PB - Macmillan Publishers Limited, part of Springer Nature CY - [London] ER -