TY  - JOUR
A1  - Wolfsgruber, Steffen
A1  - Wagner, Michael
A1  - Schmidtke, Klaus
A1  - Frölich, Lutz
A1  - Kurz, Alexander
A1  - Schulz, Stefanie
A1  - Hampel, Harald
A1  - Heuser, Isabella
A1  - Peters, Oliver
A1  - Reischies, Friedel
A1  - Jahn, Holger
A1  - Luckhaus, Christian
A1  - Hüll, Michael
A1  - Gertz, Hermann-Josef
A1  - Schröder, Johannes
A1  - Pantel, Johannes
A1  - Rienhoff, Otto
A1  - Rüther, Eckart
A1  - Henn, Fritz
A1  - Wiltfang, Jens
A1  - Maier, Wolfgang
A1  - Kornhuber, Johannes
A1  - Jessen, Frank
T1  - Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment
T2  - PLoS One
N2  - Background: Concerns about worsening memory (“memory concerns”; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI).
Methods: We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.
Results: Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33–4.89), lower memory performance (HR = 0.63, 95%CI: 0.56–0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18–3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.
Conclusions: Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34551
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-345519
SN  - 1932-6203
N1  - Copyright: © 2014 Wolfsgruber et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (7): e100812
SP  - 1
EP  - 8
PB  - PLoS
CY  - Lawrence, Kan.
ER  -