TY  - JOUR
A1  - Sicorello, Maurizio Leonardo
A1  - Herzog, Julia
A1  - Wager, Tor D.
A1  - Ende, Gabriele
A1  - Müller-Engelmann, Meike
A1  - Herpertz, Sabine
A1  - Bohus, Martin
A1  - Schmahl, Christian
A1  - Paret, Christian
A1  - Niedtfeld, Inga
T1  - Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies
T2  - Neuroimage: Reports
N2  - Pathophysiological models are urgently needed for personalized treatments of mental disorders. However, most potential neural markers for psychopathology are limited by low interpretability, prohibiting reverse inference from brain measures to clinical symptoms and traits. Neural signatures—i.e. multivariate brain-patterns trained to be both sensitive and specific to a construct of interest—might alleviate this problem, but are rarely applied to mental disorders. We tested whether previously developed neural signatures for negative affect and discrete emotions distinguish between healthy individuals and those with mental disorders characterized by emotion dysregulation, i.e. Borderline Personality Disorder (BPD) and complex Post-traumatic Stress Disorder (cPTSD). In three different fMRI studies, a total sample of 192 women (49 BPD, 62 cPTSD, 81 healthy controls) were shown pictures of scenes with negative or neutral content. Based on pathophysiological models, we hypothesized higher negative and lower positive reactivity of neural emotion signatures in participants with emotion dysregulation. The expression of neural signatures differed strongly between neutral and negative pictures (average Cohen's d = 1.17). Nevertheless, a mega-analysis on individual participant data showed no differences in the reactivity of neural signatures between participants with and without emotion dysregulation. Confidence intervals ruled out even small effect sizes in the hypothesized direction and were further supported by Bayes factors. Overall, these results support the validity of neural signatures for emotional states during fMRI tasks, but raise important questions concerning their link to individual differences in emotion dysregulation.
KW  - neuroimaging
KW  - Emotion
KW  - Borderline personality disorder
KW  - Post-traumatic stress disorder
KW  - Neural signature
KW  - Meta-analysis
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73593
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-735938
SN  - 2666-9560
VL  - 1
IS  - 2, article 100019
PB  - Elsevier
CY  - Amsterdam u.a.
ER  -