TY  - JOUR
A1  - Knethen, Andreas von
A1  - Heinicke, Ulrike Elisabeth Brigitte
A1  - Laux, Volker
A1  - Parnham, Michael J.
A1  - Steinbicker, Andrea U.
A1  - Zacharowski, Kai
T1  - Antioxidants as therapeutic aAgents in acute respiratory distress syndrome (ARDS) treatment - from mice to men
T2  - Biomedicines
N2  - Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medical need for a new therapeutic concept. One reason for a missing etiologic therapy strategy is the multifactorial origin of ARDS, which leads to a large heterogeneity of patients. This review summarizes the various kinds of ARDS onset with a special focus on the role of reactive oxygen species (ROS), which are generally linked to ARDS development and progression. Taking a closer look at the data which already have been established in mouse models, this review finally proposes the translation of these results on successful antioxidant use in a personalized approach to the ICU patient as a potential adjuvant to standard ARDS treatment.
KW  - ARDS
KW  - antioxidant
KW  - Nrf2
KW  - GSH
KW  - NADPH oxidase
KW  - SOD
KW  - electron transfer chain
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/82502
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-825027
SN  - 2227-9059
VL  - 10
IS  - 1, art. 98
SP  - 1
EP  - 24
PB  - MDPI
CY  - Basel
ER  -