TY  - JOUR
A1  - Brandt, Tobias
A1  - Mourier, Arnaud
A1  - Tain, Luke S.
A1  - Partridge, Linda
A1  - Larsson, Nils-Göran
A1  - Kühlbrandt, Werner
T1  - Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila
T2  - eLife
N2  - Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations of mitochondria from mouse liver show age-related changes in membrane morphology. Subpopulations of mitochondria from young and old mouse kidney resemble those described for apoptosis. In aged flies, respiratory activity is compromised and the production of peroxide radicals is increased. In about 50% of mitochondria from old flies, the inner membrane organization breaks down. This establishes a clear link between inner membrane architecture and functional decline. Mitochondria were affected by ageing to very different extents, depending on the organism and possibly on the degree to which tissues within the same organism are protected against mitochondrial damage.
KW  - D. melanogaster
KW  - ageing
KW  - biochemistry
KW  - biophysics
KW  - cryo-tomography
KW  - membrane structure
KW  - mitochondrial inner membrane
KW  - mouse
KW  - peroxide radicals
KW  - respiratory activity
KW  - structural biology
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44436
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-444368
SN  - 2050-084X
N1  - Copyright Brandt et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
VL  - 6
SP  - 1
EP  - 19
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -