TY  - CONF
A1  - Dubinski, Daniel
A1  - Won, Sae-Yeon
A1  - Rauch, Maximilian
A1  - Behmanesh, Bedjan
A1  - Ngassam, Lionel D. C.
A1  - Baumgarten, Peter
A1  - Senft, Christian
A1  - Harter, Patrick Nikolaus
A1  - Bernstock, Joshua D.
A1  - Freiman, Thomas Michael
A1  - Geßler, Florian
T1  - Association of Isocitrate Dehydrogenase (IDH) status with edema to tumor ratio and its correlation with immune infiltration in glioblastoma
T2  - Brain and Spine
N2  - Background: The extent of preoperative peritumoral edema in glioblastoma (GBM) has been negatively correlated with patient outcome. As several ongoing studies are investigating T-cell based immunotherapy in GBM, we conducted this study to assess whether peritumoral edema with potentially increased intracranial pressure, disrupted tissue homeostasis and reduced local blood flow has influence on immune infiltration and affects survival.
Methods: A volumetric analysis of preoperative imaging (gadolinium enhanced T1 weighted MRI sequences for tumor size and T2 weighted sequences for extent of edema (including the infiltrative zone, gliosis etc.) was conducted in 144 patients using the BrainlabÒ software. Immunohistochemical staining was analyzed for lymphocytic- (CD 3+) and myeloid (CD15+) tumor infiltration. A retrospective analysis of patient-, surgical-, and molecular characteristics was performed using medical records.
Results: The edema to tumor ratio was neither associated with progression-free nor overall survival (p=0.90, p=0.74). However, GBM patients displaying IDH-1 wildtype had significantly higher edema to tumor ratio than patients displaying an IDH-1 mutation (p=0.01). Immunohistopathological analysis did not show significant differences in lymphocytic or myeloid tumor infiltration (p=0.78, p=0.74) between these groups.
Conclusion: In our cohort, edema to tumor ratio had no significant correlation with immune infiltration and outcome. However, patients with an IDH-1wildtype GBM had a significantly higher edema to tumor ratio compared to their IDH-1 mutated peer group. Further studies are necessary to elucidate the underlying mechanisms.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77928
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-779282
SN  - 2772-5294
VL  - 1
IS  - supplement 2, 100476
PB  - Elsevier
CY  - Amsterdam
ER  -