TY  - JOUR
A1  - Platschek, Steffen
A1  - Cuntz, Hermann
A1  - Vuksic, Mario
A1  - Deller, Thomas
A1  - Jedlička, Peter
T1  - A general homeostatic principle following lesion induced dendritic remodeling
T2  - Acta Neuropathologica Communications
N2  - Introduction: Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood.
Results: Using computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjustment of excitability. As a consequence, surviving afferents are able to activate the cells, thereby allowing information to flow again through the denervated area. In addition, action potentials backpropagating from the soma to the synapses are enhanced specifically in reorganized portions of the dendritic arbor, resulting in their increased synaptic plasticity. These two observations generalize to any given dendritic tree undergoing structural changes.
Conclusions: Structural homeostatic plasticity, i.e. homeostatic dendritic remodeling, is operating in long-term denervated neurons to achieve functional homeostasis.
KW  - Electrotonic analysis
KW  - Computer simulation
KW  - Compartmental modeling
KW  - Morphological modeling
KW  - Voltage attenuation
KW  - Backpropagating action potential
KW  - Homeostatic plasticity
KW  - Granule cell
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41678
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-416783
SN  - 2051-5960
N1  - © 2016 Platschek et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
VL  - 4
IS  - 19
SP  - 1
EP  - 11
ER  -