TY  - JOUR
A1  - Vaca Llerena, Diana Jaqueline
A1  - Thibau, Arno
A1  - Schütz, Monika
A1  - Kraiczy, Peter
A1  - Happonen, Lotta
A1  - Malmström, Johan
A1  - Kempf, Volkhard A. J.
T1  - Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria
T2  - Medical microbiology and immunology
N2  - The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by “anti-ligands” to prevent colonization or infection of the host. Future development of such “anti-ligands” (specifically interfering with bacteria-host matrix interactions) might result in the development of a new class of anti-infective drugs for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. This review summarizes our current knowledge about the manifold interactions of adhesins expressed by Gram-negative bacteria with ECM proteins and the use of this information for the generation of novel therapeutic antivirulence strategies.
KW  - Gram-negative bacteria
KW  - Adhesins
KW  - Extracellular matrix proteins
KW  - Fibronectin
KW  - Collagen
KW  - Laminin
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81951
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-819512
SN  - 1432-1831
VL  - 209.2020
IS  - 3
SP  - 277
EP  - 299
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -