TY  - JOUR
A1  - Schommartz, Iryna
A1  - Lembcke, Philip F.
A1  - Pupillo, Francesco
A1  - Schuetz, Henriette
A1  - Wald de Chamorro, Nina
A1  - Bauer, Martin
A1  - Kaindl, Angela M.
A1  - Buß, Claudia
A1  - Shing, Yee Lee
T1  - Distinct multivariate structural brain profiles are related to variations in short- and long-delay memory consolidation across children and young adults
T2  - Developmental cognitive neuroscience
N2  - Highlights
• Short- and long-delay memory consolidation is less robust in children than in young adults.
• Short-delay brain profile comprised of hippocampal, cerebellar, and neocortical brain regions.
• Long-delay brain profile comprised of neocortical and selected hippocampal brain regions.
• Brain profiles differ between children and young adults.
Abstract
From early to middle childhood, brain regions that underlie memory consolidation undergo profound maturational changes. However, there is little empirical investigation that directly relates age-related differences in brain structural measures to memory consolidation processes. The present study examined memory consolidation of intentionally studied object-location associations after one night of sleep (short delay) and after two weeks (long delay) in normally developing 5-to-7-year-old children (n = 50) and young adults (n = 39). Behavioural differences in memory retention rate were related to structural brain measures. Our results showed that children, in comparison to young adults, retained correctly learnt object-location associations less robustly over short and long delay. Moreover, using partial least squares correlation method, a unique multivariate profile comprised of specific neocortical (prefrontal, parietal, and occipital), cerebellar, and hippocampal head and subfield structures in the body was found to be associated with variation in short-delay memory retention. A different multivariate profile comprised of a reduced set of brain structures, mainly consisting of neocortical (prefrontal, parietal, and occipital), hippocampal head, and selective hippocampal subfield structures (CA1–2 and subiculum) was associated with variation in long-delay memory retention. Taken together, the results suggest that multivariate structural pattern of unique sets of brain regions are related to variations in short- and long-delay memory consolidation across children and young adults.
KW  - Episodic memory
KW  - Object-scene associations
KW  - Memory consolidation
KW  - Hippocampal subfields
KW  - Prefrontal cortex
KW  - Neocortex
KW  - Partial least square correlation
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78792
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-787920
SN  - 1878-9293
VL  - 59.2023
IS  - 101192
PB  - Elsevier
CY  - Amsterdam
ER  -