TY  - JOUR
A1  - Krieg, Sara-Cathrin
A1  - Grimmer, Jennifer
A1  - Kramer, Philipp
A1  - Bolte, Michael
A1  - Kelm, Harald
A1  - Manolikakes, Georg
T1  - Oxyenamides as versatile building blocks for a highly stereoselective one-pot synthesis of the 1,3-diamino-2-ol-scaffold containing three continuous stereocenters
T2  - Angewandte Chemie
N2  - A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alcohol unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an additional stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.
KW  - 1,3-diamine
KW  - enamides
KW  - Lewis acid
KW  - one-pot reaction
KW  - stereoselective synthesis
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64492
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-644925
SN  - 1521-3773
N1  - Financial support by the DFG (MA 6093/10-1) and the research unit NanoKat at the TU Kaiserslautern is gratefully acknowledged. P. Kramer thanks the Polytechnische Gesell- schaft Frankfurt am Main (Germany) for a MainCampus PhD scholarship. Open Access funding enabled and organized by Projekt DEAL.
VL  - 60
IS  - 44
SP  - 23667
EP  - 23671
PB  - Wiley-VCH
CY  - Weinheim
ER  -