TY  - JOUR
A1  - Wells, Carrow I.
A1  - Al-Ali, Hassan
A1  - Andrews, David M.
A1  - Asquith, Christopher R. M.
A1  - Axtman, Alison D.
A1  - Đikić, Ivan
A1  - Ebner, Daniel
A1  - Ettmayer, Peter
A1  - Fischer, Christian
A1  - Frederiksen, Mathias
A1  - Futrell, Robert E.
A1  - Gray, Nathanael S.
A1  - Hatch, Stephanie B.
A1  - Knapp, Stefan
A1  - Lücking, Ulrich
A1  - Michaelides, Michael
A1  - Mills, Caitlin E.
A1  - Müller, Susanne
A1  - Owen, Dafydd R.
A1  - Picado, Alfredo
A1  - Saikatendu, Kumar S.
A1  - Schröder, Martin
A1  - Stolz, Alexandra
A1  - Tellechea, Mariana
A1  - Turunen, Brandon J.
A1  - Vilar, Santiago
A1  - Wang, Jinhua
A1  - Zuercher, William J.
A1  - Willson, Timothy M.
A1  - Drewry, David H.
T1  - The Kinase Chemogenomic Set (KCGS): an open science resource for kinase vulnerability identification
T2  - International Journal of Molecular Sciences
N2  - We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
KW  - protein kinase
KW  - kinase inhibitor
KW  - chemogenomic set
KW  - phenotypic screening
KW  - small molecules
KW  - KCGS
KW  - drug discovery
KW  - druggable genome
KW  - understudied kinase
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57697
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-576979
SN  - 1422-0067
VL  - 22
IS  - Article 566
PB  - MDPI
CY  - Basel
ER  -