TY  - JOUR
A1  - Röhling, Martin
A1  - Kempf, Kerstin
A1  - Banzer, Winfried
A1  - Braumann, Klaus Michael
A1  - Führer, Dagmar
A1  - Halle, Martin
A1  - McCarthy, David
A1  - Martin, Stephan
A1  - Scholze, Jürgen
A1  - Toplak, Hermann
A1  - Berg, Aloys
A1  - Predel, Hans-Georg
T1  - A high-protein and low-glycemic formula diet improves blood pressure and other hemodynamic parameters in high-risk individuals
T2  - Nutrients
N2  - Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2–4 weeks: 2 meals/day; 5–26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (−7.3 mmHg 95% CI [−9.2; −5.3] vs. −3.3 mmHg [−5.9; −0.8], p < 0.049) and DBP (−3.7 mmHg [−4.9; −2.5] vs. −1.4 mmHg [−3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity.
KW  - blood pressure
KW  - insulin
KW  - lifestyle intervention
KW  - formula diet
KW  - cardiac autonomic regulation
KW  - pulse wave velocity
KW  - heart rate
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/82716
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-827165
SN  - 2072-6643
N1  - Funding: Almased-Wellness-GmbH.
VL  - 14
IS  - 7, art. 1443
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  -