TY  - JOUR
A1  - Roeder, Falk
A1  - Meldolesi, Elisa
A1  - Gerum, Sabine
A1  - Valentini, Vincenzo
A1  - Rödel, Claus
T1  - Recent advances in (chemo-)radiation therapy for rectal cancer: a comprehensive review
T2  - Radiation oncology
N2  - The role of radiation therapy in the treatment of (colo)-rectal cancer has changed dramatically over the past decades. Introduced with the aim of reducing the high rates of local recurrences after conventional surgery, major developments in imaging, surgical technique, systemic therapy and radiation delivery have now created a much more complex environment leading to a more personalized approach. Functional aspects including reduction of acute or late treatment-related side effects, sphincter or even organ-preservation and the unsolved problem of still high distant failure rates have become more important while local recurrence rates can be kept low in the vast majority of patients. This review summarizes the actual role of radiation therapy in different subgroups of patients with rectal cancer, including the current standard approach in different subgroups as well as recent developments focusing on neoadjuvant treatment intensification and/or non-operative treatment approaches aiming at organ-preservation.
KW  - Rectal cancer
KW  - Chemoradiation
KW  - Review
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56902
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-569020
SN  - 1748-717X
VL  - 15
IS  - Article number: 262
PB  - BioMed Central
CY  - London
ER  -