TY  - JOUR
A1  - Vogl, Thomas J.
A1  - Engelmann, Kerstin
A1  - Mack, Martin G.
A1  - Straub, Ralf
A1  - Zangos, Stephan
A1  - Eichler, Katrin
A1  - Hochmuth, Kathrin
A1  - Orenberg, Elaine K.
T1  - CT-guided intratumoural administration of cisplatin/epinephrine gel for treatment of malignant liver tumours
T2  - British journal of cancer
N2  - To analyze prospectively the interventional and clinical aspects of computed tomography-guided direct intratumoural injection of a novel chemotherapeutic administration and the parenchymal changes of tumour and necrosis in malignant liver tumours. Eight patients with 17 colorectal liver metastases were treated with a mean of 5.1 injections and nine patients with 13 hepatocellular carcinoma nodules with a mean of 3.1 treatments with computed tomography guided local applications of a novel cisplatin/epinephrine gel. This application provides a higher local and lower systemic drug concentration. Volumes of tumour and necrosis prior and after treatment were measured by computer generated volumetric analysis. Contrast enhanced studies verified pretherapeutic viable tumour volumes with a value of 77.4 ml in the metastases and 29.2 ml in the hepatocellular carcinoma nodules. Intratumoural drug application resulted in a significant increase of necrosis and a decrease in viable tumour volume to be 68.3 ml in metastases and 14.5 ml in hepatocellular carcinoma. Local therapy control rate for the follow up to 6 months was 38 and 71% for the group of metastases and hepatocellular carcinoma, respectively. Direct intratumoural injection of cisplatin/epinepthrine injectable gel is a feasible and good tolerated method and results in the development of a statistically significant increase in necrosis in malignant liver tumours. For hepatocellular carcinoma a higher local therapy control rate compared to colorectal metastases can be reported.
KW  - locoregional chemotherapy
KW  - interventional radiology
KW  - livermetastases of colorectal cancer
KW  - hepatocellular carcinoma
Y1  - 2002
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45619
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-456196
SN  - 1532-1827
SN  - 0007-0920
N1  - From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
VL  - 86
IS  - 4
SP  - 524
EP  - 529
PB  - Nature Publ. Group
CY  - Edinburgh
ER  -