TY  - JOUR
A1  - Sturm, Ramona
A1  - Haag, Florian
A1  - Janicová, Andrea
A1  - Xu, Baolin
A1  - Vollrath, Jan Tilmann
A1  - Bundkirchen, Katrin
A1  - Dunay, Ildikò Rita
A1  - Neunaber, Claudia
A1  - Marzi, Ingo
A1  - Relja, Borna
T1  - Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers - with reduced intestinal barrier loss in female
T2  - European journal of trauma and emergency surgery
N2  - Objective: Trauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a potent immunomodulator of the post-traumatic response to tissue injury. Polytraumatized patients are frequently at risk to developing infectious complications, which may be aggravated by alcohol-induced immunosuppression. Systemic levels of integral proteins of the gastrointestinal tract such as syndecan-1 or intestinal fatty acid binding proteins (FABP-I) reflect the intestinal barrier function. The exact impact of acute alcohol intoxication on the barrier function and endotoxin bioactivity have not been clarified yet. Methods: 22 healthy volunteers received a precisely defined amount of alcohol (whiskey–cola) every 20 min over a period of 4 h to reach the calculated blood alcohol concentration (BAC) of 1‰. Blood samples were taken before alcohol drinking as a control, and after 2, 4, 6, 24 and 48 h after beginning with alcohol consumption. In addition, urine samples were collected. Intestinal permeability was determined by serum and urine values of FABP-I, syndecan-1, and soluble (s)CD14 as a marker for the endotoxin translocation via the intestinal barrier by ELISA. BAC was determined. Results: Systemic FABP-I was significantly reduced 2 h after the onset of alcohol drinking, and remained decreased after 4 h. However, at 6 h, FABP-I significantly elevated compared to previous measurements as well as to controls (p < 0.05). Systemic sCD14 was significantly elevated after 6, 24 and 48 h after the onset of alcohol consumption (p < 0.05). Systemic FABP-I at 2 h after drinking significantly correlated with the sCD14 concentration after 24 h indicating an enhanced systemic LPS bioactivity. Women showed significantly lower levels of syndecan-1 in serum and urine and urine for all time points until 6 h and lower FABP-I in the serum after 2 h. Conclusions: Even relative low amounts of alcohol affect the immune system of healthy volunteers, although these changes appear minor in women. A potential damage to the intestinal barrier and presumed enhanced systemic endotoxin bioactivity after acute alcohol consumption is proposed, which represents a continuous immunological challenge for the organism and should be considered for the following days after drinking.
KW  - Alcohol
KW  - Barrier
KW  - FABP
KW  - SCD14
KW  - Syndecan-1
KW  - Gender
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63641
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636410
SN  - 1863-9941
N1  - Open Access funding enabled and organized by Projekt DEAL. The study was supported by grants from the Deutsche Forschungsgemeinschaft (grant nos. DFG RE 3304/5-1, DFG RE 3304/9-1, DFG NE 1932/1-3 and Nachwuchsförderung AO Trauma Deutschland (R.S.).
VL  - 48.2021
IS  - 3
SP  - 1569
EP  - 1577
PB  - Springer Medizin
CY  - Heidelberg
ER  -