TY  - JOUR
A1  - Grill, Magdalena
A1  - Högenauer, Christoph
A1  - Blesl, Andreas
A1  - Haybaeck, Johannes
A1  - Golob-Schwarzl, Nicole
A1  - Ferreirós Bouzas, Nerea
A1  - Thomas, Dominique Jeanette
A1  - Gurke, Robert
A1  - Trötzmüller, Martin
A1  - Köfeler, Harald C.
A1  - Gallé, Birgit
A1  - Schicho, Rudolf
T1  - Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer
T2  - Scientific reports
N2  - Preclinical studies have demonstrated that the endocannabinoid system (ECS) plays an important role in the protection against intestinal inflammation and colorectal cancer (CRC); however, human data are scarce. We determined members of the ECS and related components of the ‘endocannabinoidome’ in patients with inflammatory bowel disease (IBD) and CRC, and compared them to control subjects. Anandamide (AEA) and oleoylethanolamide (OEA) were increased in plasma of ulcerative colitis (UC) and Crohn’s disease (CD) patients while 2-arachidonoylglycerol (2-AG) was elevated in patients with CD, but not UC. 2-AG, but not AEA, PEA and OEA, was elevated in CRC patients. Lysophosphatidylinositol (LPI) 18:0 showed higher levels in patients with IBD than in control subjects whereas LPI 20:4 was elevated in both CRC and IBD. Gene expression in intestinal mucosal biopsies revealed different profiles in CD and UC. CD, but not UC patients, showed increased gene expression for the 2-AG synthesizing enzyme diacylglycerol lipase alpha. Transcripts of CNR1 and GPR119 were predominantly decreased in CD. Our data show altered plasma levels of endocannabinoids and endocannabinoid-like lipids in IBD and CRC and distinct transcript profiles in UC and CD. We also report alterations for less known components in intestinal inflammation, such as GPR119, OEA and LPI.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55572
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-555723
SN  - 2045-2322
VL  - 9
IS  - Article number: 2358
PB  - [London]
CY  - Macmillan Publishers Limited, part of Springer Nature
ER  -