TY  - JOUR
A1  - Portas, Laura
A1  - Bauersachs, Rupert
A1  - Bowrin, Kevin
A1  - Briere, Jean-Baptiste
A1  - Cohen, Alexander
A1  - Huelsebeck, Maria
A1  - Jones, Schuyler
A1  - Quint, Jennifer K.
T1  - Assessment of the burden of disease for patients with peripheral artery disease undergoing revascularization in England
T2  - Vascular medicine
N2  - Background: Symptoms, severity, and acuteness of peripheral artery disease (PAD) are major determinants of severe limb symptoms, subsequent risk of cardiovascular events, and mortality. Lower-extremity revascularization (LER) is a key option to relieve symptoms and to prevent limb loss in symptomatic patients with PAD. This study aimed to quantify the burden of disease among patients with PAD-LER in England.
Methods: A retrospective population-based study of linked primary and secondary care electronic health records, included 13,869 adult patients (aged ⩾ 18 years) with PAD-LER from 2003 to 2018. The incidence of first ever PAD-LER was estimated both overall and by type of procedure (endovascular/surgical). Health resource utilization associated with PAD-related complications and treatment patterns were assessed.
Results: A high annual incidence of lower-limb revascularization (41.2 per 1000 person years) and a nearly double incidence of endovascular first revascularization compared with open surgery were observed. More than 70% of patients with PAD-LER had a history of hyperlipidemia and hypertension and roughly one-third were diabetic and had a history of coronary artery disease. Cardiovascular mortality accounted for one-third (34.1 per 1000 person years) of all-cause mortality. Over 93% of patients were hospitalized for any reason and the commonest reasons for hospitalization were cardiovascular diseases and PAD with about one-third hospitalized for revascularization reoccurrence. 
Conclusion: There is a significant burden of PAD-LER to the individual and society with ongoing healthcare resource utilization, treatment, and increasing mortality.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83402
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-834027
SN  - 1477-0377
SN  - 1358-863X
VL  - 27
IS  - 5
SP  - 440
EP  - 449
PB  - Sage
CY  - London
ER  -