TY  - INPR
A1  - Urschel, Rebecca
A1  - Bronder, Saskia
A1  - Klemis, Verena
A1  - Marx, Stefanie
A1  - Hielscher, Franziska
A1  - Abu-Omar, Amina
A1  - Guckelmus, Candida
A1  - Schneitler, Sophie Charlotte
A1  - Baum, Christina
A1  - Becker, Sören Leif
A1  - Gärtner, Barbara
A1  - Sester, Urban
A1  - Widera, Marek
A1  - Schmidt, Tina
A1  - Sester, Martina
T1  - SARS-CoV-2 specific cellular and humoral immunity after bivalent BA.4/5 COVID-19 vaccination in previously infected and non-infected individuals
T2  - medRxiv
N2  - Knowledge is limited as to how prior SARS-CoV-2 infection influences cellular and humoral immunity after booster-vaccination with bivalent BA.4/5-adapted mRNA-vaccines, and whether vaccine-induced immunity correlates with subsequent infection. In this observational study, individuals with prior infection (n=64) showed higher vaccine-induced anti-spike IgG antibodies and neutralizing titers, but the relative increase was significantly higher in non-infected individuals (n=63). In general, both groups showed higher neutralizing activity towards the parental strain than towards Omicron subvariants BA.1, BA.2 and BA.5. In contrast, CD4 or CD8 T-cell levels towards spike from the parental strain and the Omicron subvariants, and cytokine expression profiles were similar irrespective of prior infection. Breakthrough infections occurred more frequently among previously non-infected individuals, who had significantly lower vaccine-induced spike-specific neutralizing activity and CD4 T-cell levels. Thus, the magnitude of vaccine-induced neutralizing activity and specific CD4 T-cells after bivalent vaccination may serve as a correlate for protection in previously non-infected individuals.
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73982
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-739827
IS  - 2023.05.03.23289472
ER  -