TY  - JOUR
A1  - Chandra, Prakash
A1  - Wacker, Adolf
A1  - Süßmuth, Roland
A1  - Lingens, Franz
T1  - Zum Wirkungsmechanismus von 1-Nitroso-3-nitro-1-methyl-guanidin bei der Mutationsauslösung. 1. Wirkung von 1-Nitroso-3-nitro-1-methyl-guanidin auf die Matrizenaktivität der Polynucleotide bei der zellfreien Proteinsynthese
T2  - Zeitschrift für Naturforschung, B
N2  - The effect of NNMG on the template activities of different polynucleotides (polyuridylic acid, polycytidylic acid, polyadenylic acid and copolymer of adenylic and guanylic acid 5,5:1) and t-RNS was studied. The maximum inhibition of the messenger activity was found for poly-C, followed by poly-Α and poly-U. The acceptor activity of t-RNA was found to be inhibited by NNMG: maximum for proline, followed by serine, leucine, phenylalanine and lysine. The mechanism of these inhibitions was studied using NNMG radioactively labelled on the methyl group. Different amounts of radioactivity were found in the various polynucleotides and t-RNS.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74877
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-748770
SN  - 1865-7117
SN  - 0932-0776
VL  - 22
IS  - 5
SP  - 512
EP  - 517
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -