TY  - JOUR
A1  - Alafuzoff, Irina
A1  - Arzberger, Thomas
A1  - Al-Sarraj, Safa
A1  - Bodi, Istvan
A1  - Bogdanovic, Nenad
A1  - Braak, Heiko
A1  - Bugiani, Orso
A1  - Del Tredici, Kelly
A1  - Ferrer, Isidro
A1  - Gelpi, Ellen
A1  - Giaccone, Giorgio
A1  - Graeber, Manuel B.
A1  - Ince, Paul
A1  - Kamphorst, Wouter
A1  - King, Andrew
A1  - Korkolopoulou, Penelope
A1  - Kovács, Gábor G.
A1  - Larionov, Sergey
A1  - Meyronet, David
A1  - Monoranu, Camelia
A1  - Parchi, Piero
A1  - Patsouris, Efstratios
A1  - Roggendorf, Wolfgang
A1  - Seilhean, Danielle
A1  - Tagliavini, Fabrizio
A1  - Stadelmann, Christine
A1  - Streichenberger, Nathalie
A1  - Thal, Dietmar R.
A1  - Wharton, Stephen B.
A1  - Kretzschmar, Hans
T1  - Staging of neurofibrillary pathology in Alzheimer's disease : a study of the BrainNet Europe Consortium
T2  - Brain pathology
N2  - It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-µm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V–VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I–II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
KW  - Alzheimer's disease
KW  - immunohistochemistry
KW  - neurofibrillary pathology
KW  - neuropathological diagnosis
KW  - BrainNet Europe consortium
Y1  - 2008
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/7096
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-74382
SN  - 1015-6305
SN  - 1750-3639
N1  - Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
VL  - 18
IS  - 4
SP  - 484
EP  - 496
PB  - Blackwell
CY  - Oxford
ER  -